Association between gestational diabetes mellitus and postpartum depression: an updated systematic review and meta-analysis
Abstract
The aim of this study is to provide a robust statistical analysis of the association between gestational diabetes mellitus (GDM) and postpartum depression (PPD). For this purpose, the PRISMA statement guided the reporting of results, while the MOOSE guidelines informed the methodological aspects. This strategy includes searching in several electronic databases. Statistical heterogeneity between studies was assessed using the Q-statistic and I-squared (I2) test. The final included studies comprised 29 studies with a total of 2,442,001 participants. Overall results showed that mothers with GDM are at a higher risk of developing PPD compared to mothers without GDM (RR = 1.42 (95 %CI: 1.17-1.72, P < 0.001)). To investigate potential sources of heterogeneity, subgroup analyses based on study design (P = 0.085), study type (P = 0.357), duration of PPD measurement (P = 0.329), and continent (P = 0.163) were not significant, but it was significant based on the PPD measurement tool (P < 0.001). Finally, the results of this systematic review and meta-analysis provide strong evidence that GDM is an important risk factor for PPD. These findings underscore the critical importance of screening and providing targeted psychological and therapeutic support to mothers with GDM, both during pregnancy and after delivery.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,442,001 participants or records.
Read the paper
Related studies
- Understanding the factors influencing fall armyworm (Spodoptera frugiperda J.E. Smith) damage in African smallholder maize fields and quantifying its impact on yield. A case study in Eastern Zimbabwe
- Alarming situation of emerging H5 and H7 avian influenza and effective control strategies
- Livestock and food security: vulnerability to population growth and climate change
- Atmosphere–ocean oxygen and productivity dynamics during early animal radiations
- Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9
- The global seroprevalence of Toxoplasma gondii in pigs: A systematic review and meta-analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.