Classification and Genotype–Phenotype Relationships of GBA1 Variants: MDSGene Systematic Review
Abstract
Depending on zygosity and the specific change, different variants in the GBA1 gene can cause Parkinson's disease (PD, PARK‐GBA1) with reduced penetrance, act as genetic risk factors for PD or parkinsonism, and/or lead to Gaucher's disease (GD). This MDSGene systematic literature review covers 27,963 patients carrying GBA1 variants from 1082 publications with 794 variants, including 13,342 patients with PD or other forms of parkinsonism. It provides a comprehensive overview of demographic, clinical, and genetic findings from an ethnically diverse sample originating from 82 countries across five continents. The most frequent pathogenic or likely pathogenic variants were “N409S” (aka “N370S”; dominating among Jewish and Whites), and “L483P” (aka “L444P”; dominating among Asians and Hispanics), whereas the most common coding risk variants were “E365K” (E326K), and “T408M” (T369M) (both common among Whites). A novel finding is that early‐onset PD patients were predominantly of Asian ethnicity, whereas late‐onset PD patients were mainly of White ethnicity. Motor cardinal features were similar between PD patients and other forms of parkinsonism, whereas motor complications and non‐motor symptoms were more frequently reported in PD patients carrying “severe” variants than in those with “risk” or “mild” variants. Cognitive decline was reported in most patients after surgical treatment, despite achieving a beneficial motor function response. Most GD patients developing PD harbored the…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 27,963 participants or records.
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