S4: The LatAm-FINGERS Initiative: The First Non-Pharmacological Randomized Controlled Trial to Prevent Cognitive Decline Across Latin America
Abstract
Overview: Gustavo E. Sevlever Approximately 40% of global dementia cases in high-income countries are attributed to potentially modifiable risk factors, whereas in Latin America, this figure rises to 56%. This difference underscores the importance of initiating preventive trials in the region. LatAm- FINGERS is the first non-pharmacological multicenter randomized clinical trial in Latin America, involving 12 countries: Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Ecuador, Mexico, Puerto Rico, the Dominican Republic, and Uruguay. The trial aims to prevent cognitive impairment through a multidomain lifestyle intervention. It evaluates the feasibility and efficacy of these interventions in enhancing cognitive function among 1,200 participants over two years. The lifestyle intervention, modeled after the Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), encompasses nutrition, physical exercise, cardiovascular risk factor management, cognitive training, and socialization. Harmonization processes have ensured consistency with FINGER and the U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) across Latin America. Since recruitment commenced in December 2021, 1,867 participants have been screened, with 1,186 enrolled. The cohort is predominantly female (73.8%), with an average age of 67.41 years, representing diverse ethnic backgrounds. LatAm-FINGERS has established the largest dataset on…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 1,867 participants or records.
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