Central Nervous System Germ Cell Tumors: Discrepancies in Diagnosis and Management Across the World
Abstract
Intracranial germ cell tumors (iGCTs) constitute a rare and heterogeneous group, with significant variations in their prevalence and management strategies across all continents. Through numerous prospective clinical trials across the globe, the treatment of iGCTs has steadily advanced with improvement in outcomes. However, a universally accepted standard-of-care treatment for these tumors remains elusive, with varied diagnostic criteria and treatment regimens employed among oncologists in North America (Children’s Oncology Group [COG]), Europe (International Society of Pediatric Oncology [SIOP]), and Asia. Furthermore, there is a wide variation in the management of iGCTs in the young adult population, owing to sparse literature in this specific age group. Our review aims to highlight the discrepancies in diagnosis and management of iGCTs globally, with the goal of addressing those gaps and helping inform future clinical trial design.
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