Regenerative endodontic procedures: mapping and critical appraisal of clinical trial evidence.
Abstract
INTRODUCTION
Regenerative endodontic procedures (REPs) are biologically based approaches aimed at restoring the vitality of immature teeth with pulp necrosis. Over the past decades, these procedures have gained increasing attention. This study mapped and critically appraised the clinical trial evidence on regenerative endodontic procedures, providing an overview of research trends and methodological characteristics.
METHODOLOGY
A comprehensive bibliometric analysis was conducted following BIBLIO guidelines using the Web of Science Core Collection (WoS-CC) database. Randomized and non-randomized clinical trials available in the database up to 2025 were included, covering the full period of indexed clinical evidence on REPs. Quantitative variables (citations, countries, journals, keywords) and qualitative aspects (techniques, materials, irrigants, intracanal medications, and barriers) were analyzed.
RESULTS
Among the 6,287 retrieved records, 58 clinical studies met the inclusion criteria. The most productive authors were De-Jesus-Soares A, Gomes BPFA, Kang J, Nazzal H, and Elheeny AAH. The most cited author was Xuan K, with 346 citations. Asia was the most productive continent, and the Journal of Endodontics published the highest number of studies. The most frequent keywords were regenerative endodontics, revascularization, and immature teeth. Blood clot induction was the predominant regenerative technique, while sodium hypochlorite, triple antibiotic paste, and MTA were the…
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