Hidradenitis Suppurativa and IL-17 Inhibitors: A Focus on Trials and Real-Life Data
Abstract
Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease associated with significant physical and psychosocial burden. Increasing evidence identifies the interleukin (IL)-17 pathway as a central driver of HS pathogenesis. Elevated levels of IL-17 family cytokines, particularly IL-17A and IL-17F, have been consistently demonstrated in lesional skin, where they contribute to keratinocyte activation, neutrophil recruitment, and amplification of proinflammatory cascades. This review provides a comprehensive overview of the pathogenic role of IL-17 in HS and summarizes current evidence on IL-17-targeted therapies from clinical trials and real-world studies. Secukinumab, a selective IL-17A inhibitor, has shown significant efficacy in phase III trials, with clinically meaningful improvements in Hidradenitis Suppurativa Clinical Response (HiSCR), pain, and quality of life, sustained over long-term follow-up. Bimekizumab, a dual inhibitor of IL-17A and IL-17F, has demonstrated robust and consistent efficacy across multiple endpoints, including higher response rates and greater improvements in patient-reported outcomes, supporting the relevance of dual cytokine inhibition. Despite these advances, treatment responses remain heterogeneous, reflecting the multifactorial nature of HS. Further research is needed to identify predictive biomarkers and optimize therapeutic strategies.
Read the paper
Related studies
- Understanding the factors influencing fall armyworm (Spodoptera frugiperda J.E. Smith) damage in African smallholder maize fields and quantifying its impact on yield. A case study in Eastern Zimbabwe
- Alarming situation of emerging H5 and H7 avian influenza and effective control strategies
- Livestock and food security: vulnerability to population growth and climate change
- Atmosphere–ocean oxygen and productivity dynamics during early animal radiations
- Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9
- The global seroprevalence of Toxoplasma gondii in pigs: A systematic review and meta-analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.