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Burdens of neck pain in China from 1990 to 2021 and its projection to 2050: Findings from the Global Burden of Disease study 2021

Zhao G, Zhang X, Zhao X, Zhang S, Zhang H

Pakistan journal of medical sciences, 2026

Abstract

Background & objective: This study aimed to assess the burden of neck pain from 1990 to 2021 and predict its trends over the next three decades, providing evidence for targeted interventions.

Methodology: This study is a secondary analysis of publicly available national-level estimates for China from the Global Burden of Disease (GBD) 2021 study released by the Institute for Health Metrics and Evaluation, covering 1990-2021, with projections to 2050. The age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), and age-standardized disability-adjusted life years (DALYs) rate for neck pain were calculated. Temporal trends were evaluated using estimated annual percentage changes (EAPC). The age-period-cohort (APC) model was employed to explore underlying drivers of disease burden, while the Bayesian-APC (BAPC) model was applied to predict future trends.

Results: In 2021, the ASIR, ASPR, and age-standardized DALYs rate for neck pain in China were 567.23 (95% uncertainty interval [UI]: 448.497 - 699.796, per 100000 population), 2549.87 (95% UI: 2007.887 - 3141.637, per 100000 population), and 254.77 (95% UI: 166.889 - 357.934, per 100000 population), respectively. Between 1990 and 2021, the EAPCs for ASIR, ASPR, and age-standardized DALYs rates were 0.08% (95%CI: 0.06 - 0.11), 0.13% (95%CI: 0.10 - 0.16), and 0.13% (95%CI: 0.10 - 0.16), respectively. APC analysis identified age as the dominant contributing factor, with the highest burden observed in the 70…

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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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