Clinical outcomes of neobladder or augmentation after cystectomy in locally advanced colorectal cancer involving urinary tract: case series
Abstract
BACKGROUND: In most cases of colorectal cancer (CRC) with bladder invasion, ileal conduit (urostomy) is commonly performed. However, with increasing survival rates, quality of life becomes a significant concern, making this approach less favorable. Thus, this study aims to investigate the clinical outcomes of patients with CRC who underwent neobladder or augmentation surgery. METHODS: We retrospectively reviewed the records of nine patients who underwent neobladder or augmentation surgery combined with surgical management of locally advanced CRC involving the urinary tract between 2011 and 2018 at Asan Medical Center. RESULT: Nine patients with rectal or sigmoid colon cancer underwent neobladder or augmentation surgery following total or partial cystectomy. The median operative time was 341 min (range, 208–459 min), and the median urinary tract reconstruction time was 125 min (range, 66–255 min). Early complications occurred in three patients, and one patient experienced a late complication requiring surgical repair. At one year, seven patients achieved full continence without the need for clean intermittent catheterization. With a median follow-up of 56 months, five patients were disease-free, three had persistent disease, and one had died of disease. CONCLUSION: Quality of life is crucial for CRC patients with improved survival rates. Neobladder or augmentation surgery are feasible options for CRC patients with urinary tract invasion.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Understanding the factors influencing fall armyworm (Spodoptera frugiperda J.E. Smith) damage in African smallholder maize fields and quantifying its impact on yield. A case study in Eastern Zimbabwe
- Alarming situation of emerging H5 and H7 avian influenza and effective control strategies
- Livestock and food security: vulnerability to population growth and climate change
- Atmosphere–ocean oxygen and productivity dynamics during early animal radiations
- Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9
- The global seroprevalence of Toxoplasma gondii in pigs: A systematic review and meta-analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.