Blood Pressure Indices in Children with Sickle Cell Disease, of Age 8-18 Yrs. at a Tertiary Care Centre in Chhattisgarh- A Cross Sectional Study
Abstract
Sickle cell disease is the commonest haemoglobinopathy. Anaemia leads to a hyperdynamic circulation, decreased systemic resistance, and sickle polymerization causing hyperviscosity, natriuresis and hyposthenuria that blunt the maximal plasma volume expansion interplay to affect blood pressure indices. Asian and African continents have a high share of sickle cell population, being historically malaria endemic areas. These populations have previously witnessed early death due to complications from sickle cell disease. With the recent advanced therapeutic approaches, sickle cell patients are surviving beyond adulthood. Increased survival has resulted in a new subset of sickle cell patients which is exposed to the effects of persistent haemolytic anaemia and the haemodynamic alterations. These effects have not been studied in sickle cell patients in the state of Chhattisgarh. Most of the studies conclude that sickle subjects have lower systolic, diastolic and mean blood pressure and higher pulse pressure. - blood pressure, diastolic blood pressure, mean blood pressure and pulse pressure between sickle and control subjects. Data was tabulated for 50 patients of sickle cell disease and 50 healthy controls without any haemoglobinopathy. The study concluded that the mean systolic blood pressure in sickle cell patients and control group was 119.46 ± 8.32 & 117.14 ± 8.10 (p=0.161), the diastolic blood pressure was 73.42 ± 7.88 & 72.60 ± 6.62 (p=0.575), mean blood pressure was 137.71 ±…
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