Global mapping of sexually transmitted Chlamydia trachomatis disease: a systematic review and meta-analysis
Abstract
BACKGROUND: Chlamydia trachomatis (C. trachomatis) is known as a leading cause of one of the most prominent sexually transmitted diseases (STD) worldwide. A meta-analysis was performed in this study to comprehensively determine the prevalence of C. trachomatis in the STD population. METHOD: PubMed/Medline, Embase, and Web of Science databases were used to conduct an extensive literature search on relevant papers published from 2000 to 2023. After that, statistical analysis was performed utilizing comprehensive meta-analysis (CMA) software (version 2.0, Biostat, USA) to report the global prevalence of C. trachomatis in the STD population. RESULT: In prevalence studies involving an overall number of 40,159 STD individuals, 17,289 C. trachomatis isolates were collected in 86 countries worldwide, either by culture or by indirect DNA testing. The pooled prevalence of C. trachomatis within the global STD population was 41.6% (95% CI,40.1–43%), while a higher rate was recorded for males (12807 vs. 18871). The prevalence of C. trachomatis infection was highest in Oceania, followed by Europe, America, Asia, and Africa (49.9%, 46.3%, 41.3%, 41.1%, and 36.1%, respectively). According to data from case reports and case series, lymphogranuloma venereum (LGV) and human immunodeficiency virus (HIV) infection were the most common concurrent diseases and co-infections. CONCLUSION: The elevated prevalence of C. trachomatis in 86 countries suggests that innovative screening and…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 40,159 participants or records.
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