Global prevalence of psittacosis in outbreaks: a systematic review and meta-analysis
Abstract
Background: Psittacosis is a globally underappreciated and frequently undiagnosed zoonotic disease, and it is often difficult to determine the number of individuals exposed to Chlamydia psittaci. Despite numerous reported cases and outbreaks worldwide, there has been no systematic assessment of psittacosis prevalence to date, which is crucial for evaluating the disease burden and developing vaccines. Our objective is to evaluate the global prevalence of psittacosis in outbreaks.
Methods: We conducted a comprehensive search across multiple databases, including PubMed, Web of Science, Cochrane Library, and Medline, from the date of establishment to May 15, 2024. Additionally, we manually searched reference lists of included articles and retrieved reviews to identify any supplementary articles. The primary summary data was the prevalence of psittacosis in the outbreaks. Pooled estimates of prevalence were calculated for both the entire population and subgroups using a random-effects model.
Results: Thirty-one eligible studies from 13 countries across four continents were included in this review. The pooled prevalence of psittacosis among 4,158 exposed individuals in outbreaks was 27.7% (95% CI: 20.9-34.9). Meta-regression analysis of six potential influencing factors (geographic region, outbreak sites, outbreak season, infectious source, publication year, and study quality) indicated that the source of heterogeneity may be associated with the outbreak sites (P = 0.031).…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 4,158 participants or records.
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