Molecular and phylogenetic characterization of Staphylococcus aureus isolated from primary pyoderma in a goat from tropical India: an emerging zoonotic threat
Abstract
Staphylococcus aureus is a globally prevalent zoonotic pathogen frequently associated with pyoderma in humans; however, molecular data on primary staphylococcal pyoderma in Indian goats are meagre. This report presents the first molecular identification and phylogenetic analysis of S. aureus from a goat with primary pyoderma, along with clinical management. A four-month-old Malabari crossbred goat kid was presented to the Teaching Veterinary Clinical Complex, Mannuthy, with pustules and scab-like lesions on perianal and abdominal skin. Dermatological evaluation indicated primary pyoderma, and impression smears revealed Gram-positive cocci and neutrophils. The isolate was catalase positive and exhibited sensitivity to tetracycline, gentamicin, amoxicillin-sulbactam, ceftriaxone-tazobactam, and streptomycin, but showed resistance to multiple antibiotics. The isolate was identified as S. aureus by 16S rRNA gene sequencing. BLAST analysis revealed 99.48% sequence identity with S. aureus strains isolated from human cases of sepsis and pyoderma in Uzbekistan, India, and the USA, as well as with a complete genome sequence of a human blood isolate from Brazil. Phylogenetic analysis further demonstrated clustering with human isolates reported from multiple continents. A combination therapy of ceftriaxone-tazobactam and gentamicin for seven days based on culture and sensitivity test led to complete recovery. The genetic proximity to human pathogenic strains across diverse regions…
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