Abstract B120: A call for a modernized TNBC/mTNBC clinical trial: Ensuring equity, precision medicine, and survivorship for young Black women
Abstract
While the median age of breast cancer diagnosis in the U.S. is 61, over 14,000 women under 40 are diagnosed annually and early onset cancers are on the rise globally. The magnitude and speed at which early onset cancer incidence has increased is unlike most cancer trends ever observed. This phenomenon has been observed on all continents, in men and women, and in many cancer sites. Younger Black women face a disproportionate burden of aggressive triple-negative breast cancer (TNBC) and metastatic TNBC (mTNBC), with a 40% higher mortality rate than White women—a gap unchanged for 25 years. Black women are three times more likely to develop TNBC, often with larger and more aggressive tumors, making breast cancer the leading cause of cancer death for women ≤40. Despite precision medicine advances and guideline driven integrative care approaches, young Black women remain underrepresented in research and face significant systemic barriers to equitable care. Evidence-based integrative oncology services- such as psychosocial support, stress reduction, nutrition counseling, and yoga- are recommended by national guidelines to complement treatment yet remain underutilized in clinical trials. What is the definitive, proven therapy for newly diagnosed Black Women with TNBC/mTNBC?
A comprehensive review of FDA-approved TNBC/mTNBC PH3/pivotal trials (2020–2025) assessed representation and outcomes for young Black women. Inclusion criteria required trials to be completed or have reported…
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