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Clinical complications and anthropometric indicators of chronic kidney disease in a global context: scoping review

Muniz VM, de Paiva Souza Klippel L, Freitas KLF, Dos Santos Barbosa K, Libardi MC, de Paula Alves Bezerra OM, da Cunha AC, Naseri AP et al.

Pediatric nephrology (Berlin, Germany), 2026

50 participants

Abstract

Background: Pediatric chronic kidney disease (CKD) is a serious public health problem and represents a considerable burden on health systems, particularly in low- and middle-income countries (LMICs). Despite well-documented global disparities in CKD management, the extent of these differences across continents remains insufficiently explored, particularly in pediatric populations.

Objective: To explore the body of recent evidence on clinical complications and anthropometric indicators of CKD in childhood and to identify gaps in knowledge that can guide the development of future studies of CKD in childhood, in the global context.

Data sources: Studies were searched in following electronic databases: PubMed/Medline, Embase, Web of Science, and Google Scholar.

Study eligibility criteria: Inclusion criteria consisted of observational quantitative articles (cohort, cross-sectional, case-control studies) in English that evaluated CKD in children. We excluded studies without reported data findings, case studies with fewer than 50 individuals and conducted with the same cohort.

Participants and interventions: Children and adolescents aged 0 to 18 years old with CKD.

Study appraisal and synthesis methods: This research did not aim to evaluate the quality of individual studies, since the main objective of a scoping review is to map the evidence and identify strengths and weaknesses. We conducted a scoping review structured using the methodology developed by Arksey and O'Malley…

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