Herd-level seroprevalence, molecular prevalence, and trends of Coxiella burnetii (Q fever) in cattle worldwide: A systematic review and meta-analysis
Abstract
Background and aim: Cattle are the reservoir host of Coxiella burnetii, a causative agent of Q fever. Pooling herd-level prevalence data from individual studies would help determine the global prevalence of C. burnetii in cattle herds. This study aimed to estimate the global herd-level seroprevalence and molecular prevalence of C. burnetii in cattle, explore sources of heterogeneity, and determine trends and cumulative evidence of the pooled prevalence over time.
Materials and methods: Relevant studies were retrieved from PubMed, Scopus, and Web of Science and then screened for possible inclusion. A random-effects model was used for all meta-analyses. Subgroup meta-analysis and meta-regression were used to explore some sources of heterogeneity associated with the pooled prevalence and to determine the trends of C. burnetii in cattle herds over the study years (1961-2020). A cumulative meta-analysis was used to determine the cumulative evidence of the pooled prevalence over the publication years.
Results: Of the 1541 citations, 86 studies with 38,057 cattle herds from 42 countries on six continents were included in the meta-analysis. The global herd-level seroprevalence of C. burnetii in cattle was estimated to be 44.4% (95% confidence interval [CI], 37.9%-51.1%), with high heterogeneity among the included studies. The herd-level seroprevalence was significantly higher in dairy than in beef cattle herds (49.0% [95% CI: 41.9%-56.2%] vs. 14.5% [95% CI: 5.8%-32.1%],…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Understanding the factors influencing fall armyworm (Spodoptera frugiperda J.E. Smith) damage in African smallholder maize fields and quantifying its impact on yield. A case study in Eastern Zimbabwe
- Alarming situation of emerging H5 and H7 avian influenza and effective control strategies
- Livestock and food security: vulnerability to population growth and climate change
- Atmosphere–ocean oxygen and productivity dynamics during early animal radiations
- Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9
- The global seroprevalence of Toxoplasma gondii in pigs: A systematic review and meta-analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.