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Diagnosis and Management of Colorectal Cancer in the Gulf Area: Current Practice and Future Suggestions from Expert Opinions

Al-Shamsi HO, Rasul Snr K, Shablak A, ALnajjar A, Shabaan AMA, Al Sindi M, Nasr M, AlJabban A et al.

OncoTargets and therapy, 2025

1 citation

Abstract

Colorectal cancer (CRC) is one of the most diagnosed cancers, leading to considerable cancer-related deaths globally. Recently, a notable increase has been observed in annual CRC incidence rates, particularly among individuals aged ≤50 years. Rapid urbanization and lifestyle changes have contributed to this trend. Early diagnosis through structured screening programs remains crucial for improving prognosis, yet uptake in the Gulf remains suboptimal due to limited public awareness and gaps in the national screening infrastructure. Diagnostic approaches in the region increasingly incorporate advanced imaging modalities and molecular testing, although access to in-house testing facilities is limited, often resulting in delays in personalized therapy initiation. Treatment strategies for CRC in the Gulf are guided by international guidelines, and are tailored according to tumor characteristics, molecular profile, and patient status. Multidisciplinary teams in tertiary centers facilitate evidence-based management, while ongoing efforts aim to expand access to targeted therapies and optimize care pathways. Insufficient training, limited knowledge, and suboptimal communication between primary care providers and specialists have been identified. Also, limited in-house molecular testing often leads to outsourcing, causing delays in targeted therapy and higher treatment costs. In this perspective article, we provide an overview of current practices and propose future perspectives for…

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