Comparative Distribution of High-Risk Human Papillomavirus (HPV) Genotypes in India vs World Health Organization Regions and Countries: Implications for HPV Vaccination
Abstract
Background: High-risk human papillomavirus (HPV)-induced cervical cancer is a major cause of mortality worldwide. Published data suggest geographic variations in the prevalence of some of the 12 high-risk HPV genotypes. Although the variations in prevalence of the 2 most common high-risk HPV genotypes-16 and 18-have been relatively well documented, the variations in prevalence of the other 10 high-risk genotypes are not as well documented. Reliable proof of variations in prevalence may warrant different high-risk HPV vaccine compositions/vaccination strategies in specific geographic areas. To explore the adequacy of the HPV vaccines available in India, we focused this study on the following: (1) confirming that high-risk HPV genotype variations exist on the Indian subcontinent, (2) determining how the genotype variations differ from the variations in other WHO regions/countries and among different regions/states in India, (3) determining whether any regional variations are sufficiently different to warrant changes in high-risk HPV vaccine compositions and/or vaccination strategies, and (4) determining whether the collected data could lead to new hypothesis generation and study design.
Methods: We used 2 methods to gather information. To examine variations in prevalence, we conducted a secondary analysis (data mining) of publicly available data from the HPV Information Centre. The HPV Information Centre data were obtained from a systematic review of studies published from…
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