In Vitro Activity of Cefiderocol, a Siderophore Cephalosporin, Against Gram-Negative Bacilli Isolated by Clinical Laboratories in North America and Europe in 2015-2016: SIDERO-WT-2015
Abstract
ABSTRACT Cefiderocol (S-649266) is a parenteral siderophore cephalosporin in phase III of clinical development. In this study, we determined the in vitro susceptibility to cefiderocol and comparators of a 2015-2016 collection of 8954 clinical isolates of Gram-negative bacilli (GNB), provided by 100 clinical laboratories in North America and Europe, using the Clinical and Laboratory Standards Institute broth microdilution method. Iron-depleted cation-adjusted Mueller-Hinton broth was used to test cefiderocol. The concentration of cefiderocol inhibiting 90% of isolates (MIC 90 ) was 0.5 mg/L (North America; n =2470) and 1 mg/L (Europe; n =3,543) for Enterobacteriaceae, 0.5 mg/L (North America; n =619) and 0.5 mg/L (Europe; n =921) for Pseudomonas aeruginosa , 1 mg/L (North America; n =308) and 2 mg/L (Europe; n =664) for Acinetobacter spp., 0.5 mg/L (North America; n =165) and 0.25 mg/L (Europe; n =175) for Stenotrophomonas maltophilia , and 0.12 mg/L (North America; n =40) and 0.5 mg/L (Europe; n =49) for Burkholderia cepacia complex spp. Cefiderocol MICs were ≤4 mg/L for 99.9% (6005/6013) of Enterobacteriaceae, 99.9% (1539/1540) of P. aeruginosa , 96.4% (937/972) of Acinetobacter spp., 99.4% (338/340) of S. maltophilia , and 94.4% (84/89) of Burkholderia cepacia complex spp. isolates tested. Against meropenem-non-susceptible isolates, MICs to cefiderocol were ≤4 mg/L for 99.6% (245/246) of Enterobacteriaceae, 99.7% (394/395) of P. aeruginosa , 96.1% (540/562) of…
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