Beyond fifth disease: atypical parvovirus B19 neurological syndromes in adults-first series from the West Bank
Abstract
Parvovirus B-19 (B19-PV) infection is usually a self-limiting illness that occurs in children, although there have been reported cases affecting older people and presenting with a wide range of symptoms, especially neurological ones. The diagnosis can be tricky and can cost time; therefore, knowledge of this infectious etiology and how it manifests can aid physicians in prompt and timely diagnosis, as time is vital in such cases in order to preserve organ functions and prevent life-threatening complications. Herein, we report Parvovirus B19-associated clinical features and workup in a series of five patients with laboratory-confirmed B19-PV from 2024 to 2025, which, to our knowledge, is the first case series in the West Bank of Palestine. The mean age of our population was 60.5 years, with a sex ratio (male: female) of 3:2, though of note, males were all above 60 and all females were under 50, mainly presenting with neurological manifestations.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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