Use of echinocandins combined with clindamycin in Pneumocystis pneumonia: a case series of 14 patients
Abstract
BACKGROUND
Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection for which the standard of care is co-trimoxazole. However, safety concerns and intolerance may compromise its utility.
OBJECTIVES
To evaluate the safety and efficacy of the combination of echinocandins and clindamycin to treat PcP.
PATIENTS AND METHODS
We investigated 14 patients treated with a co-trimoxazole-free combined regimen that included echinocandins and clindamycin.
RESULTS
Clinical cure was achieved in 8 out of 14 patients, while 5 had a fatal outcome due to their primary disease; however, only one patient died due to PcP.
CONCLUSIONS
Echinocandin and clindamycin may be a safe and effective alternative treatment for patients who cannot be given co-trimoxazole for PcP.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 14 participants or records.
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