Organizing pneumonia in hospitalized COVID-19 patients: risk factors and long-term outcomes
Abstract
Some patients develop post-COVID-19 organizing pneumonia (OP) that is responsive to corticosteroid treatment. This multicenter, case-control study of patients hospitalized for COVID-19 sought to determine the prevalence, risk factors, radiological outcomes, and evolution after treatment. We included 153 consecutive patients with OP and 140 without OP who required hospitalization because of COVID-19 from February to April 2020. OP patients were followed up for 12 months, with visits at 1, 3, 6, and 12 months after hospital discharge. Risk factors for OP at hospital admission were advanced age, previous respiratory disease, and elevated C-reactive protein levels. Follow-up computed thoracic (CT) scans performed one year after admission showed progressive improvement in radiological involvement; however, up to 57% of patients with OP remained with fibrotic-like changes. Multivariate analysis showed a significant association of fibrotic pattern with older age, high dose of corticosteroids, and extensive parenchymal lung involvement on admission CT scans. Following COVID-19 OP, fibrotic-like changes may persist over the long term. Higher dose of corticosteroids does not seem to be associated with a better prognosis.
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 153 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.