Could Xuebijing Injection Reduce the Mortality of Severe Pneumonia Patients? A Systematic Review and Meta‐Analysis
Abstract
Background and Aim. Xuebijing injection (XBJ) is a Chinese traditional medicine preparation, mainly made from Carthamus tinctorius flowers (Honghua in Chinese), Paeonia lactiflora roots (Chishao), Ligusticum chuanxiong rhizomes (Chuanxiong), Salvia miltiorrhiza roots (Danshen), and Angelica sinensis roots (Danggui). It can reduce inflammation and regulate blood coagulation and immune function. XBJ has been used in severe pneumonia patients in China. Whether it can reduce the mortality of patients is still controversial. This study aimed to analyze the effectiveness of XBJ in the treatment of severe pneumonia. Methods. Databases including PubMed, Cochrane Library, Web of Science, Embase, CNKI, WanFang, and VIP were searched, from inception to February 2020, to identify randomized controlled trials (RCTs) about XBJ combined with western medicine treatment in treating severe pneumonia. Literature screening, data extraction, and methodological quality assessment were carried out by two researchers back‐to‐back. RevMan 5.3 software was used for statistical analysis. Results. A total of 21 articles involving 2072 patients were included. The meta‐analysis showed that treatment combined with XBJ has better efficiency compared with western medicine treatment alone. It could also decrease 28‐day mortality; shorten the length of intensive care unit (ICU) stay time and mechanical ventilation time; and reduce the levels of C‐reactive protein (CRP), procalcitonin (PCT), white blood cell…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,072 participants or records.
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