P123 Management challenges in rheumatoid arthritis-associated interstitial lung disease: insights from a real-world case series
Abstract
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a significant extra-articular manifestation that affects approximately 10% of RA patients and contributes to increased morbidity and mortality. The most common radiological patterns are usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), with variable clinical progression. Diagnosis is often delayed due to subtle respiratory symptoms and lack of routine screening. Treatment remains challenging, with limited data guiding immunosuppressive or antifibrotic use. This case series explores the clinical features, diagnostic timelines, pulmonary function profiles, and therapeutic strategies in RA-ILD, highlighting real-world challenges and variability in patient management across multidisciplinary settings.
We conducted a retrospective case-series of patients with confirmed rheumatoid arthritis-associated interstitial lung disease (RA-ILD) managed at our centre. Clinical data including demographics, ILD subtype, RA serostatus, smoking history, referral patterns, pulmonary function tests (PFTs), and treatment regimens were extracted from patient records. Ten patients were identified (5 males, 5 females), with a median age of 75.1 years (range 56–86). ILD subtype was confirmed by high-resolution CT in all cases: 4 patients had usual interstitial pneumonia (UIP), 4 had nonspecific interstitial pneumonia (NSIP), and 2 had early unclassified ILD. The median time lag from RA diagnosis to…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.