In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates
Abstract
The in vitro activity of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, was tested against 2,440 clinical isolates. Nemonoxacin was at least fourfold more active than levofloxacin and moxifloxacin against most gram-positive cocci tested (shown by the following MIC(90)/range [microg/ml] values; community-associated methicillin [meticillin]-resistant Staphylococcus aureus, 0.5/0.015 to 2; Staphylococcus epidermidis, 0.5/0.015 to 4 for methicillin-susceptible staphylococci and 2/0.12 to 2 for methicillin-resistant staphylococci; Streptococcus pneumoniae, 0.015/ or = 512; Klebsiella pneumoniae, 2/ or = 512; Pseudomonas aeruginosa, 32/ or = 512; Acinetobacter baumannii, 1/0.12 to 16).
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