Comparison of Levofloxacin Alone and Azithromycin Combined with Amoxicillin and Clavulanate Potassium for Patients with Community-acquired Pneumonia
Abstract
To evaluate the efficacy,the safety and cost-effectiveness in patients with community-acquired pneumonia( CAP) in comparison with therapy using levofloxacin alone and using a combination of azithromycin plus amoxicillin and clavulanate potassium.Methods 80 patients with light and moderate CAP were randomly divided into two groups:levofloxacin alone and azithromycin plus amoxicillin,and the efficacy,the side-effect and the cost-effectiveness were observed.Results From 43 patients in the levofloxacin group,35 patients( 81.4% ) were clinically cured and 4 patients( 9.3% ) were improved.The total effective rate was 90.7% .And from 37 patients in the azithromycin plus amoxicillin group,30 patients( 81.1% ) were clinically cured and 4 patients( 10.8% ) were improved.The total effective rate was 91.9% .The rates of side effects were 9.3% and 8.1% respectively.And the average cost of the treatment were 52.5yuan and 90.9 yuan respectively.Conclusion There are no significant differences in the efficacy and the safety between the 2 groups in treating community-acquired pneumonia.Yet the levofloxacin is superior to azithromycin plus amoxicillin and clavulanate potassium in comparison with the cost-effectiveness.
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