Efficacy of sildenafil combined with statins in treating pulmonary hypertension secondary to chronic obstructive pulmonary disease
Abstract
AIMS
This study aims to comprehensively assess the effectiveness and safety of combining sildenafil with statins for managing pulmonary hypertension secondary to COPD. By conducting a comprehensive meta-analysis, we seek to provide robust evidence to inform and optimize clinical decision-making for this challenging condition.
METHODS
A systematic search of the literature was performed across various databases, such as CNKI, VIP Data, Wanfang Data, PubMed, Web of Science, and the Cochrane Library, to identify RCTs that assess the effectiveness of sildenafil and statins in combination for treating PH secondary to COPD.The search included all records available from the establishment of each database until October 2024.Data extraction and meta-analysis were carried out with RevMan 5.3 software. The primary outcome measures comprised 6MWD and mPAP. The secondary outcome measures included FEV1/FVC, hs-CRP,and PaO2.
RESULTS
Our study encompassed a total of 12 randomized controlled trials involving 937 patients who all come from China.Our research findings indicate that Sildenafil combined with statins could enhance 6MWD,lower mPAP,rise FEV1/FVC and PaO2, reduce hs-CRP of COPD-PH,in contrast to the control group.Adverse reactions associated with the combination therapy were generally mild and tolerable.
CONCLUSION
This combination therapy not only improves patients' exercise capacity, as evidenced by increased 6MWD, but also alleviates PH and enhances overall quality of life.…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 937 participants or records.
Read the paper
Related studies
- 2024 update in heart failure
- Vascular involvement in idiopathic pulmonary fibrosis
- A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study
- Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
- Combined Pulmonary Fibrosis and Emphysema (CPFE): A "New" Smoking-Related Interstitial Lung Disease (ILD)
- Impact of an acute 1-month cannabidiol treatment on pain and inflammation after a long bone fracture: a triple-blind randomised, placebo-controlled, clinical trial protocol
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.