Distribution of virulence-associated genes and antimicrobial susceptibility in clinical Acinetobacter baumannii isolates
Abstract
// Chao Liu 1, * , Yaowen Chang 1, * , Ying Xu 2 , Yun Luo 1 , Linrong Wu 1 , Zhanjun Mei 1 , Shigang Li 1 , Rui Wang 1 and Xu Jia 1 1 Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, Sichuan, China 2 Clinical Laboratory, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China * These authors have contributed equally to this work Correspondence to: Rui Wang, email: [email protected] Xu Jia, email: [email protected] Keywords: Acinetobacter baumannii; antimicrobial resistance; MDR; virulence genes; PFGE Received: December 11, 2017 Accepted: February 26, 2018 Published: April 24, 2018 ABSTRACT Acinetobacter baumannii is undoubtedly one of the most clinically significant pathogens. The multidrug resistance and virulence potential of A. baumannii are responsible for hospital-acquired nosocomial infections. Unlike numerous investigations on the drug-resistant epidemiology of A. baumanni , virulence molecular epidemiology is less studied. Here, we collected 88 A. baumannii clinical isolates, tested their antimicrobial susceptibility to 10 commonly used antibiotics and analyzed the distribution of 9 selected virulence-associated genes, aims to investigate the primary characteristics of the virulence-associated genes that exist in clinically multidrug resistant (MDR) and non-MDR isolates of A. baumannii . The MIC results showed the resistance rates of ciprofloxacin (68.2%, 60/88), gentamicin (67.0%, 59/88),…
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