Drugs for preventing tuberculosis in people at risk of multiple-drug-resistant pulmonary tuberculosis
Abstract
Background: The emergence and spread of multiple-drug-resistant tuberculosis (MDR-TB), caused by strains of Mycobacterium tuberculosis resistant to at least isoniazid and rifampicin, is a potential threat to global tuberculosis control. Treatment is prolonged, expensive, more toxic than treatment of susceptible tuberculosis, and often unsuccessful. Experts are still undecided on the management of people exposed to MDR-TB.
Objectives: To evaluate antituberculous drugs given to people exposed to MDR-TB in preventing active tuberculosis.
Search strategy: We searched the Cochrane Infectious Diseases Group Specialized Register (January 2006), CENTRAL (The Cochrane Library 2006, Issue 1), MEDLINE (1966 to January 2006); EMBASE (1974 to January 2006), LILACS (1982 to January 2006), conference proceedings, and reference lists. We also contacted researchers and organizations.
Selection criteria: Randomized controlled trials comparing antituberculous drug regimens with an alternative antituberculous drug regimen, placebo, or no intervention given to people exposed to MDR-TB for preventing active tuberculosis.
Data collection and analysis: Two authors independently inspected titles and abstracts identified by the search in order to identify potentially relevant publications for inclusion and analysis.
Main results: No randomized controlled trials met the inclusion criteria.
Authors' conclusions: The balance of benefits and harms associated with treatment for latent tuberculosis…
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Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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