A Fatal Infection Caused by Dolosigranulum Pigrum in a Patient with Lung Cancer: A Case Report
Abstract
Dolosogranulum Pigrum is a rare gram-positive catalase-negative coccus and a commensal organism residing in the upper respiratory tract that can cause fatal opportunistic infections in immunocompromised patients. In this report, we describe a case of a 62-year-old male patient affected by metastatic lung cancer treated with chemotherapy, radiotherapy and immunotherapy, who had dyspnea and positive blood cultures for the bacterium Dolosigranulum Pigrum, associated with bilateral interstitial pneumonia, initially confused with pneumonia related to SARS-CoV-2 infection. Although Dolosigranulum Pigrum appears to be very susceptible to current antibiotics, as ampicillin, ceftriaxone, levofloxacin, and vancomycin, it can cause serious infections in humans, particularly in patients with baseline pulmonary diseases, such as lung cancer, cystic fibrosis, and severe chronic obstructive pulmonary disease, until the patient’s death.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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