Domperidone, Parkinson disease and sudden cardiac death: Mice and men show the way
Abstract
Sudden cardiac death (SCD) is a highly visible tragedy that generates intense debate among medical experts, members of scientific communities and laypersons alike. By definition, SCD is usually reported as unexpected death within one hour of the onset of a change in clinical status as the result of cardiovascular events in a person with or without preexisting heart disease 1,2. The pathophysiology of SCD is heterogeneous, but SCD is caused by electric instability and lethal ventricular arrhythmias followed by hemodynamic collapse 1. From an epidemiological perspective, according to recent, well-designed prospective studies conducted in different countries, SCD rates range from 50 to 100 cases per 100,000 in the general population 1,. In the same studies, “sudden” death also occurred in many patients with acute catastrophic neurological diseases or chronic neurological disorders with acute decompensation 9. Following this line of reasoning and because Parkinson disease (PD) has been neglected in this field of research, it is appropriate to consider the possible occurrence of SCD among individuals with PD and highlight these possibilities in the current scientific scenario.
PD is one of the most common, age-related neurodegenerative disorders and is characterized by tremors, muscular rigidity, slowed movement and postural imbalance that results from progressive neuronal loss in specific brain regions 10,11,12. PD affects approximately 0.3% of adult individuals in general, more…
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