Tadalafil protects against renal fibrosis after ischemia-reperfusion injury by inhibiting Akt/NF-κB signaling pathway
Abstract
Renal fibrosis is a common feature of chronic kidney diseases, characterized by a complex and dynamic process involving the infiltration of inflammatory cells, abnormal formation and deposition of the extracellular matrix, and damage to the kidney's intrinsic cells. Renal fibrosis can lead to end-stage renal disease, but developing antifibrotic drugs remains a significant challenge. Phosphodiesterase 5 inhibitors have anti-apoptotic and antioxidant properties, making them promising candidates for treating ischemia-reperfusion injuries. However, no phosphodiesterase 5 inhibitors are currently approved for kidney disease treatment. This study evaluated the therapeutic effects of Tadalafil, a long-acting phosphodiesterase 5 inhibitor, in a murine model of unilateral renal ischemia-reperfusion injury. Mice underwent 45 minutes of renal ischemia followed by reperfusion and were then randomized to receive Tadalafil (1 mg/kg/day or 3 mg/kg/day) via oral gavage or vehicle control. Treatment began 2 hours post-injury and continued for 11 consecutive days. The results showed that Tadalafil could reduce excessive extracellular matrix deposition and inflammatory cell infiltration, as well as improve renal tissue structural damage and glomerular filtration function. Furthermore, Tadalafil significantly inhibited mesangial cell proliferation and activation induced by Angiotensin II. Mechanistically, Tadalafil was found to inhibit the activation of the Protein Kinase B (Akt)/Nuclear Factor…
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
- Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- Effectiveness of Low-Intensity Extracorporeal Shock Wave Therapy in Erectile Dysfunction: An Analysis of Sexual Function and Penile Hardness at Erection: An Umbrella Review
- Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.