Retrospective comparative analysis of the efficacy of treatment modalities for erectile dysfunction; are the regenerative treatments effective?
Abstract
Background: Erectile dysfunction(ED) is a prevalent sexual that is commonly treated with phosphodiesterase type 5 inhibitors (PDE5Is). Regenerative modalities such as platelet-rich plasma(PRP) and low-intensity extracorporeal shockwave therapy(Li-ESWT) have gained attention for their potential to promote tissue repair and neurovascular regeneration. However, comparative data evaluating their effectiveness alone or in combination with standard therapies remain limited. This study assessed treatment outcomes across commonly used ED modalities, with a particular focus on regenerative approaches.
Methods: 121 men with ED were evaluated. Demographic and clinical characteristics, laboratory parameters and erectile function assessments (IIEF-15, SHIM, PEDT) were recorded at baseline and 3-month follow-up. Treatment modalities included PDE5Is, Li-ESWT, PRP injections and their combinations. Standardized protocols were applied: all PDE5I users received a 3-month regimen of tadalafil 5 mg; patients completing 6 ESWT sessions or 3 PRP sessions were analyzed.
Results: Significant improvements were observed in all erectile function measures. IIEF-15 and SHIM scores increased markedly post-treatment, while PEDT scores decreased. Categorical analyses confirmed substantial shifts toward higher erectile function levels and reduced premature ejaculation severity. Treatment modality significantly influenced ΔIIEF-15, with combination therapies demonstrating greater improvement than…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 121 participants or records.
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