Evaluation the reno-protective effect of tadalafil alone and in combination with ascorbic acid in AKI model in rats
Abstract
Background: Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, particularly in high-risk patients.
Objectives: This study aimed to evaluate the potential reno-protective effects of Tadalafil, a selective phosphodiesterase-5 (PDE-5) inhibitor, alone and in combination with ascorbic acid, in a cisplatin-induced AKI rat model.
Methods: Thirty male albino rats (250-300 g) were randomly divided into five groups: control (A), cisplatin-treated (B), ascorbic acid-treated (100 mg/kg) (C), Tadalafil-treated (5 mg/kg) (D), and combined ascorbic acid + Tadalafil (E). Treatments were administered for 10 days prior to a single intraperitoneal dose of cisplatin (10 mg/kg). After 72 h, blood and kidney tissue samples were collected for biochemical and histopathological analyses. Serum urea and creatinine, as well as renal tissue levels of NGAL, SOD, and TNF-α, were evaluated.
Results: Cisplatin significantly increased urea, creatinine, TNF-α, and NGAL levels, while reducing SOD compared to control. Pre-treatment with Tadalafil, alone or in combination with ascorbic acid, significantly ameliorated these alterations.
Conclusions: Tadalafil in combination with ascorbic acid shows enhanced protective effects, suggesting greater protective effect role. Further studies are required to confirm its clinical applicability.
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