Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box-Behnken optimization design
Abstract
- 900 and 5-400 ng mL- were 20 of citalopram and tadalafil. Box-Behnken design as a response surface methodology (RSM) used for fitting models and optimization process by the set of factors that would result in the optimum value of the response specifically designed for this method.. Under optimum conditions, the linear dynamic ranges for an estimation respectivelyat Δλ=60 nmfor citalopram and tadalafil The proposed method depends on measuring the amplitudes of the second derivative of synchronous fluorescence intensity at a suitable wavelength of 301 nm and 367 nm . There is a severe overlap between the broad-band of conventional fluorescence spectra of both drugs and their related synchronous fluorescence intensity. Therefore, development of a highly sensitive second derivative synchronous fluorescence method has been demonstrated to remove this overlap. either in their pure form, tablet dosage forms or spiked human plasmafor simultaneous determination of citalopram and tadalafilsatisfactorily selected and applied has been administered antidepressant and sexual stimulation drug in biological fluids is a very critical and important step in psychotic and ischemic heart disease patient especially in emergency case and this requires their therapeutic drug monitoring. A sensitive, efficient and rapid assay-… ..This is the first study focusing solely on the determination of tadalafil in the presence of citalopram as an antidepressant drug. Determination of co1- with detection…
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
- Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- Effectiveness of Low-Intensity Extracorporeal Shock Wave Therapy in Erectile Dysfunction: An Analysis of Sexual Function and Penile Hardness at Erection: An Umbrella Review
- Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.