Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men
Abstract
Obesity is a chronic disease of multifactorial etiology that develops from the interaction of the influence of nutritive , metabolic , cellular and molecular psychological factors.
Tadalafil is Is a drug inhibiting the enzyme phosphodiesterase-5 (PDE-5), responsible for inactivating the vasodilator nitric oxide. USING paragraph was mainly treat erectile dysfunction, and recently approved for the treatment of pulmonary hypertension , it is innovative because of its longer life means, provides efficacy after 36 hours and the highest selectivity.
The aim of this study is to evaluate the effect of tadalafil on insulin sensitivity and insulin secretion in obese men.
The investigators hypothesis is that the administration of tadalafil improve the insulin sensitivity and insulin secretion in obese men.
Conditions: Obesity.
Primary outcome: Fasting Glucose; Postprandial Glucose; First Phase of Insulin Secretion; Total Insulin Secretion; Insulin Sensitivity; Area Under the Curve (AUC) Glucose; Area Under the Curve (AUC) Insulin.
Enrollment: 18 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 18 participants or records.
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