Investigational and Comparative Study to Assess Safety and Effectiveness of Tadalafil and Pentoxifyllin in the Management of Diabetic Nephropathy
Abstract
The objective of this study is to investigate and compare the safety and efficacy of selective (PDE5) enzyme inhibitor; tadalafil and non selective (PDE) inhibitor; pentoxifylline in diabetic nephropathy to improve glucose metabolism, lipid profile and decrease albuminuria.
Conditions: Diabetic Nephropathy Type 2.
Primary outcome: Change in Urinary albumin/creatinine ratio (ACR); Change in Hemoglobin A1c (HbA1c).; Change in Fasting blood glucose.; Change in Sr Cr; Change in Creatinine clearance; change in 2- Hours Postprandial blood glucose.
Enrollment: 90 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 90 participants or records.
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