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Safety And Efficacy Of L-Arginine Monotherapy Versus Tadalafil Monotherapy Versus Their Combination In Men With Erectile Dysfunction; A Prospective Randomized Study

ClinicalTrials.gov · COMPLETED, 2025

180 participants

Abstract

Introduction Sexual dysfunctions are annoying health problems with the erectile problems forming the main part of them. Erectile dysfunction (ED) is defined as the persistent inability to obtain or maintain an erection that is sufficient to allow satisfactory sexual intercourse.\[1\] Aim of Work To evaluate the role of L-arginine monotherapy versus Tadalafil monotherapy versus their combination for the treatment of erectile dysfunction .

Patients and methods:

Inclusion criteria:

• Naive ( not previously treated) male patient with mild to moderate ED according to SHIM Questionnaire.

Exclusion criteria:

* Kidney disease or liver failure

* Coronary heart disease

* Peyronie's disease

* Neurological disease that may related to ED

Conditions: Erectile Dysfunctions.

Primary outcome: SHIM questionnaire.

Enrollment: 180 participants.

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 180 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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