Effect of PDE5 Inhibition on Adipose Metabolism in Humans
Abstract
This is a randomized, double-blinded, placebo-controlled study of the effects of PDE5 inhibition with tadalafil on adipose tissue in obese individuals. Adipose metabolism will be measured using magnetic resonance imaging (MRI) scans and by aspirating a small amount of adipose to measure gene expression.
Conditions: Obesity.
Primary outcome: Thermoneutral FSF of WAT at the Level of the Umbilicus at 12 Weeks.; Thermoneutral Subcutaneous Adipose Tissue Expression of UCP1 (Normalized Expression Units) at 12 Weeks..
Enrollment: 99 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 99 participants or records.
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