Low-dose tadalafil improves arterial erectile dysfunction
Abstract
OBJECTIVE: To evaluate the effect of low-dose phosphodiesterase type 5 inhibitor tadalafil on arterial erectile dysfunction.
METHODS: Forty-three patients with arterial erectile dysfunction were requested to take 5 mg tadalafil after supper on alternate days for 4 weeks. All the patients were scored on IIEF-5 and received intracavernous injection of 10 microg prostaglandin E1, followed by measurement of the peak systolic velocity (PSV) of the cavernosal artery by color Doppler ultrasonography.
RESULTS: Statistic analyses showed an obvious increase in the IIEF-5 score and PSV after the treatment, with significant differences from the baseline (P < 0.01).
CONCLUSION: Low-dose tadalafil can significantly improve the PSV of the cavernosal artery and hence the erectile function of arterial ED patients.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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