The Effects of Tadalafil on Optical Coherence Tomography, Optical Coherence Tomography Angiography and Ganglion Cell Complex Parameters in Patients with Erectile Dysfunction
Abstract
Abstract Purpose To investigate the short and long-term effects of Tadalafil on macular and peri-optic disc choroidal thickness, retinal vascular density, and GCC thickness in patients with erectile dysfunction. Methods Patients with erectile dysfunction who were candidates to treat with 10 mg of Tadalafil every other day and didn’t use any type of phosphodiesterase 5 inhibitors (PDE5I) in the previous 6 months and had normal eye exams were included. Macular and peri-optic disc choroidal thickness, superficial and deep retinal vascular density, and Macular Ganglion Cell Complex (GCC) thickness were measured before (baseline), one day, and 3 months after Tadalafil treatment. The measurements before and after treatment were compared. Results Thirty-one eyes of 16 patients with a mean age of 53.7 (42 to 68) years were included. After Tadalafil consumption, the choroidal thickness in the sub-macular (13.8%) and peri-optic disc (14.9%) area and also the vascular density of superficial (9.6%) and deep (9.8%) retinal capillary plexus was increased on the first day. After 3 months, we found a decremental pattern in all initially increased parameters, although sub-macular and peri-papillary choroidal thickness are yet thicker than the baseline. The retinal ganglion cell complex (GCC) average thickness was not significantly changed, neither on the first day nor after three months. Conclusions Tadalafil can increase the retinal vascular density and choroidal thickness early after…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 16 participants or records.
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
- Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- Effectiveness of Low-Intensity Extracorporeal Shock Wave Therapy in Erectile Dysfunction: An Analysis of Sexual Function and Penile Hardness at Erection: An Umbrella Review
- Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.