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From Pulmonary Hyperlucency to Pulmonary Hypertension: A Case Report of Swyer-James-MacLeod Syndrome

Montoya L JP, Vasquez J, Uribe González R, Guzman-Medina M, Palacio-Arango V

Cureus, 2025

Abstract

Swyer-James-MacLeod syndrome (SJMS) is a rare condition characterized by unilateral pulmonary hyperlucency and vascular alterations secondary to post-infectious bronchiolitis obliterans. It is also an underdiagnosed disease due to the nonspecificity of its symptoms, which highlights the importance of complementary imaging studies for its identification. Although treatment is mostly conservative, in selected cases, surgical management can improve the prognosis and quality of life of patients. We present the case of an adult female with recurrent respiratory infections in childhood who had an incidental diagnosis of SJMS with pulmonary hypertension as a complication.

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