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Utilizing Apple Vision Pro for Mindfulness Intervention to Reduce Pain and Anxiety in a Hospitalized Patient With Mixed Connective Tissue Disease: A Case Report

Azar P, Wong J, Nikoo M, Li VW, Machado J, To T, Haslam C, Mullen R et al.

Cureus, 2026

Abstract

Developing and evaluating non-pharmacological treatments is critical for optimizing pain management and reducing dependence on opioids, as well as mitigating opioid-induced adverse effects. One promising approach involves the use of virtual reality (VR)- and augmented reality (AR)-guided mindfulness techniques. We examined the clinical utility of the Mindfulness app on the Apple Vision Pro VR/AR headset in managing pain and anxiety in a hospitalized patient with mixed connective tissue disease. This case study presents a 22-year-old woman experiencing progressive acute-on-chronic pain and weakness, significantly impairing her mobility due to mixed connective tissue disease. The case report evaluated the effectiveness of a built-in Mindfulness app provided through AR on the Vision Pro. Conducted over 48 hours, the study assessed pain, anxiety, and as-needed medication usage before, during, and after the intervention for a single subject. The patient participated in six intervention sessions, each averaging 59.67 minutes in duration. The Mindfulness app on the device reduced pain from an average of 4.67/10 pre-intervention to 1.83/10 post-intervention (p=0.03) and anxiety from an average of 6.5/10 pre-intervention to 2.83/10 post-intervention (p=0.03). The patient reported an overall positive experience with a motivation to utilize mindfulness interventions further in the future. The patient experienced some discomfort with the device due to its suboptimal fit and tolerable…

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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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