Plasmon-Enhanced Fluorescence Determination of Tamsulosin Using Silver Nanoparticles: A Green Analytical Strategy
Abstract
A novel, simple, and highly sensitive spectrofluorometric method was developed for the quantification of Tamsulosin (TAM) in methanol, utilizing silver nanoparticles (AgNPs) as fluorescence enhancers. The AgNPs formed colloidal dispersions with particle sizes ranging between 5 and 50 nm, enhancing TAM's native fluorescence through a catalytic interaction. Fluorescence emission was measured at 315 nm after excitation at 285 nm, and the method exhibited linearity in the range of 100-500 ng/ml. The method was successfully applied to the assay of two commercial TAM capsule formulations obtained from a local pharmacy. Validation was carried out in accordance with International Council for Harmonisation (ICH) guidelines, confirming the method's accuracy, precision, and robustness. Furthermore, the ecological impact of the proposed method was evaluated using greenness assessment tools, including AGREE and the Analytical Eco-Scale, demonstrating its sustainability in terms of solvent use, chemical consumption, energy efficiency, and waste reduction.
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