39 Oral Tadalafil Speeds Reepithelialization and Reduces Erythema of Partial Thickness Burns in Swine
Abstract
Burns are dynamic injuries that tend to progress in depth over several days. Currently, there are no FDA-approved therapies aimed at reducing burn injury progression. We have previously demonstrated that tadalafil (a phosphodiesterase-5 inhibitor used as a vasodilator to treat erectile dysfunction) reduces necrosis in the unburned interspaces compared with naproxen, NAC, or their combination in a rat comb burn model. In this study we tested the hypothesis that tadalafil would speed reepithelialization and reduce scarring of deep partial thickness burns in a validated vertical progression porcine burn model. A validated animal burn model was used in which 60 deep partial thickness burns were created on the backs and flanks of anesthetized domestic pigs (25–30 kg) using an aluminum bar preheated to 80 degrees C for 20 seconds. After removing the necrotic epidermis to simulate blister formation and rupture, the animals were randomly treated with oral tadalafil 2.5 mg or a placebo immediately after injury and once daily thereafter for seven days. All wounds were treated with a topical triple antibiotic ointment every other day. Periodic imaging and full thickness biopsies were conducted to monitor healing over 28 days. The mean percentages wound reepithelialization at days 8, 11, 15, 18, 21, and 28 for wounds treated with tadalafil and placebo were 14±2% vs. 3±4%, 28±39% vs. 1±2%, 88±30% vs. 21±33%, 95±19 vs. 72±40, and 98±13% vs. 97±8% respectively (p<0.01 for all except day…
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