Tadalafil treatment improves the cardiovascular dysfunction and overactive bladder in heart failure rats
Abstract
Heart failure (HF) is a major public health issue, with an increasing prevalence in the world. Studies have shown a strong association of HF with development of low urinary tract symptoms (LUTS), where approximately 34% of men and 62% of women with HF reported having LUTS. Moreover, 57% of these HF patients present with overactive bladder syndrome. Dysfunction of the autonomic nervous system and alterations in important signaling pathways such as the nitric oxide/cyclic guanosine monophosphate pathway (NO‐GCs‐GMPc) are present in the HF. Therefore, drugs were synthesized to potentiate the effect exerted by NO, such as Tadalafil. Recent studies have shown that daily treatment with Tadalafil has been effective in decreasing symptoms related to urination and urine storage, in addition to improving the quality of life of patients with LUTS who have or not associated erectile dysfunction. Thus, using the aortocaval fistula model (FAC) we investigated the contribution of chronic treatment with tadalafil in the cardiovascular dysfunction and low urinary tract alterations of HF rats. HF was surgically induced through the FAC model and after 8 weeks of the surgical procedure the animals were divided into 4 groups: Sham and HF (0.9% saline solution) and Sham/Tadalafil and HF/Tadalafil (tadalafil 5mg/day for more 4 weeks). After 12 weeks, HF group presented increased left ventricle (LV) mass, decreased ejection fraction and increased LV end‐systolic and diastolic volumes when compared…
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