Formulation and evaluation of nanosuspensions of tadalafil using different stabilizers
Abstract
In the present study, an attempt was made to prepare oral nanosuspension of Tadalafil. Tadalafil is a PDE5 inhibitor used for treating erectile dysfunction (ED) and pulmonary arterial hypertension. Tadalafil nanosuspensions were prepared by nanoprecipitation method using different polymers (such as sodium lauryl sulphate (SLS), TWEEN-80, TWEEN-20, Pluronic F127 and acetone). Estimation of Tadalafil was carried out spectrophotometrically at 285 nm. The oral nanosuspension were evaluated for various physical and biological parameters, drug content uniformity, particle size analysis, zeta potential, in-vitro drug release, short-term stability, drug- excipient interactions (FTIR). Out of the formulation from F1 to F12, F11 containing TWEEN-20 (0.3%) showed 99.74% release at the end of 30 min & it follows first order drug release kinetics.
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
- Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- Effectiveness of Low-Intensity Extracorporeal Shock Wave Therapy in Erectile Dysfunction: An Analysis of Sexual Function and Penile Hardness at Erection: An Umbrella Review
- Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.