Formulation Development and Evaluation of Tadalafil Transdermal Patches Using Various Penetration Enhancers
Abstract
Ms. Shikha Baghel Chauhan The aim of this research study was to develop transdermal Patch of tadalafil using various skin penetration enhancers in different concentrations like Eugenol, 1Octanol,DMSO and Peppermint oilfor erectile dysfunction and to understand the role of penetration enhancer on the drug delivery in transdermal patch. The physicochemical compatibility and preformulation studies of the drug and the polymers was studied by Infrared spectroscopy and HPLC. Different formulation of transdermal patches using Chitosan 4% w/w as polymer and polyethylene glycol 400 and glycerol (1:1) as plasticizerwere fabricated.The results suggested no physicochemical incompatibility between the drug and the polymers. Formulated patches were evaluated for folding endurance, thickness, weight uniformity, percentage moisture content, percentage moisture uptake, content uniformity in-vitro permeation studies and in-vitro drug release were performed in 50% v/vethanolic phosphate buffer of pH 7.4.The result showed that formulation DMSO-5 found to be best formulation, as it permeated 59.42% drug through rat Dorsal skin as compare of control patch. Overall results of all permeation enhancers stated that DMSO was found to be the best penetration enhancer, as it has the best penetration ability for tadalafil transdermal drug delivery.
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