Formulation, optimization and evaluation of oral dissolving films of tadalafil solid dispersion
Abstract
The objective of the present study was to develop solid dispersion of Tadalafil with HPMC E3 and formulate an oral dissolving film for the treatment of hypertension and erectile dysfunction with enhanced disintegration, morphological properties, and optimal mechanical strength.Hydroxy propyl methyl cellulose E50 was used as a hydrophilic film-forming polymer and propylene glycol as a plasticizer.The solvent casting technique was used for preparing the films.Parameters such as In-vitro disintegrating time, tensile strength, content uniformity, folding strength, swelling index, and in vitro drug release were evaluated.3 2 factorial designs were used to optimize the amount of polymer and plasticizer.In vitro dissolution studies showed that 99% of Tadalafil was released within 10 minutes with a mean disintegration time of 20 seconds in the F9 formulation.Polynomial regression analyses were done to study the effect of plasticizer and polymer on disintegrating time, folding strength, and in vitro drug release.FTIR spectroscopy was used to determine drug-excipient interactions.SEM study showed a smooth surface of the optimized formulation.
Read the paper
Related studies
- Protective effects of tadalafil and N-acetyl cysteine therapy on cisplatin-induced testicular toxicity
- The Use of Generative AI for Scientific Literature Searches for Systematic Reviews: ChatGPT and Microsoft Bing AI Performance Evaluation
- Sildenafil as a Candidate Drug for Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
- Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- Effectiveness of Low-Intensity Extracorporeal Shock Wave Therapy in Erectile Dysfunction: An Analysis of Sexual Function and Penile Hardness at Erection: An Umbrella Review
- Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.