Physician-rated patient preference and patient- and partner-rated preference for tadalafil or sildenafil citrate: results from the Canadian 'Treatment of Erectile Dysfunction' observational study
Abstract
OBJECTIVE: To determine physician-based ratings of patient preference, patient preference, partner preference and physician-based assessment of the reasons for patient preference for tadalafil or sildenafil citrate (sildenafil) as a treatment for erectile dysfunction (ED) in routine clinical practice. Phosphodiesterase type 5 inhibitors (PDE5i) are effective and well-tolerated therapies for ED, but patient and partner preferences for these treatments might be determined by many factors, both medical and nonmedical.
PATIENTS AND METHODS: The Treatment of ED (TED) observational trial was a multicentre study conducted in Canada to determine patient and partner preferences for the PDE5i tadalafil or sildenafil in routine clinical practice. Patients who planned to change treatment from tadalafil or sildenafil to the alternative drug were invited to participate in the study. The study duration was 4-12 weeks. At visit 1 (baseline), patient background information was collected. At visit 2, physicians answered the physician-rated patient-treatment preference questionnaire, patients answered the treatment preference question (TPQ) and the global assessment question (GAQ), and partners answered the partner TPQ.
RESULTS: The TED study was conducted at 266 sites across Canada and involved 2425 patients who used the allowed study medications, and 295 sexual partners who attended clinic visits. More than 98% of patients completed the study. Responses to the preference questionnaires…
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