The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis
Abstract
Background: Purpose: to establish if exercise training improves clinical outcomes in people with metabolic syndrome (MetS). Registered with PROSPERO international prospective register of systematic reviews ( https://www.crd.york.ac.uk/PROSPERO/Identifier:CRD42017055491 ).
Data sources: studies were identified through a MEDLINE search strategy (1985 to Jan 12, 2017), Cochrane controlled trials registry, CINAHL and SPORTDiscus.
Study selection: prospective randomized or controlled trials of exercise training in humans with metabolic syndrome, lasting 12 weeks or more.
Results: We included 16 studies with 23 intervention groups; 77,000 patient-hours of exercise training. In analyses of aerobic exercise studies versus control: body mass index was significantly reduced, mean difference (MD) -0.29 (kg m-2) (95% CI -0.44, -0.15, p 2 was significantly improved MD 3.00 mL kg-1 min-1 (95% CI 1.92, 4.08, p -1 (95% CI -0.32, -0.01, p = 0.04); triglycerides were significantly reduced MD -0.21 mmol L-1 (95% CI -0.29, -0.13, p -1 (95% CI -0.05, -0.00, p = 0.02). In analyses of combined exercise versus control: waist circumference, MD -3.80 cm (95% CI -5.65, -1.95, p 2 MD 4.64 mL kg-1 min-1 (95% CI 2.42, 6.87, p < 0.0001); systolic blood pressure MD -3.79 mmHg (95% CI -6.18, -1.40, p = 0.002); and high density lipoprotein (HDL) MD 0.14 (95% CI 0.04, 0.25, p = 0.009) were all significantly improved. We found no significant differences between outcome measures between the two exercise…
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